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36,37 A structural Zn II atom nucleates folding around four metalliganding residues that are often closely spaced in the primary structure, which then induces the folding of a subdomain of a protein, organizing a surface that promotes proteinprotein or protein-nucleic acid (DNA or RNA) interactions

ANG can be conjugated to a variety of carriers to deliver small molecular drugs and genetic materials to the brain

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It is not intended to treat any condition by itself

Public Health Implications The FDA review presents a challenging dilemma for public health in the United States